Matamoros is a city with a diverse culture and significant historical attractions. However, safety can be a concern for solo female travelers. This is due to occasional instances of crime such as theft and drugs-associated violence present in the city. While many tourists and locals do not encounter any issues, it's best to stay vigilant and follow general safety precautions, including avoiding secluded and poorly lit areas during late hours, not displaying valuable possessions, and using a reliable taxi service.