Los Barriles is generally quite safe for solo female travelers. The area is home to many expatriate retirees and is known for its friendly community. It's normal to find locals offering help or advice. However, like any travel destination, it is recommended to stay vigilant, particularly at night, and adhere to common safety measures such as not flaunting expensive belongings and avoiding deserted areas. The crime rate is relatively low compared to larger cities, but minor instances like pickpocketing can occasionally occur.