Public transportation in Southern Thailand and the Andaman Coast is generally safe, but may pose some concerns during late hours. There is a strong network of buses, taxis, tuk-tuks, and boats to navigate the region. Nevertheless, it's critical to negotiate fares prior to travel to avoid any potential issues. Keep your belongings secure at all times, particularly in crowded places. Be sure to prioritize licensed and reputable transportation providers for your safety. Lastly, it's always beneficial to have a basic understanding of the local language to assist in communication.