Qarshi is generally a safe place for solo female travelers. The locals are friendly and crime rate is relatively low. However, local societal norms may be different, so it's important to respect these. Uzbekistan generally has a conservative culture, so appropriate dressing is important. Always use licensed taxis and avoid walking alone at night in less crowded areas. If possible, partner with a certified local guide. As in any other city, stay alert and be aware of your surroundings. Keep emergency numbers handy.