Samarkand is generally very safe for solo female travelers. Locals are typically hospitable and respectful towards visitors, and violent crime is relatively rare. It's recommended to be cautious during late night hours and always be aware of your surroundings. As in any other city, there are instances of petty theft or pickpocketing especially in crowded markets or public transportation, but these risks can be minimized by taking appropriate precautions. An overall safe and enriching travel destination.