Ayr is generally very safe for solo female travelers. There's an overall low crime rate and the locals are known to be amiable and helpful. However, it's always essential to take normal safety precautions, such as being aware of your surroundings and keeping your belongings secure. Public transportation is reliable and walking around the town, even after dark, is typically secure. But it goes without saying, exercise caution during late-night hours if you are alone.