Gaziantep is a generally safe city, with lower levels of crime than many other global cities. However, as a solo female traveler, you should maintain an observant and cautious attitude like you would in any large city. Turkish people are known for their hospitality, and many of them speak English, thus communication would not be a major issue. It's always important to respect local customs and attire. Also, be aware of your surroundings during nighttime, particularly in less crowded areas. It's recommend to avoid overland travel to the south close to the Syrian border due to regional instabilities.