Generally, Puerto Maldonado is a relatively safe place for solo female travelers. Crime rates are lower compared to other areas of Peru. Nevertheless, it's prudent to always be vigilant, especially during the night. Stay in crowded and well-lit areas, do not flaunt expensive items, and always have your accommodations and transport prearranged. Local people are typically friendly and helpful. Constituting the gateway to the Southern Amazon, most local businesses are dependent on tourism and take safety very seriously. However, like any other travel destination, you should always take general precautions for your safety.