While Tuscaloosa is generally a safe place for solo travelers, it is still an urban area and it's wise to exercise general safety precautions. It's home to the University of Alabama so it tends to be lively, especially during football season. Always be aware of your surroundings, especially if you're traveling around at night. Public transportation is reliable and it is safe to navigate around during the daytime. However, as with any place, it's best to avoid walking alone at night in less crowded areas or neighborhoods that are known to be less safe.