Panama City is generally safe for solo female travelers. Like any other large city in the U.S., it has areas where one needs to stay cautious, especially after dark. Overall, locals are quite friendly and welcoming. Violent crimes are relatively low, but occasional petty crimes like pickpocketing can happen, particularly in crowded public places. It's important to maintain standard safety procedures like being aware of your surroundings, not flaunting expensive gadgets, and taking trusted forms of transportation.