Manitowoc, overall is a safe city to visit as a solo female traveler. It's a relatively small city with a friendly community and low crime rate. However, as with any travel, it is still crucial to stay vigilant, especially at night and in less crowded areas. Ensure you stay in well-lit areas and keep your belongings securely at all times. Local people are generally helpful and welcoming, and local authorities assist, should you need any.