Hannibal, located in the state of Missouri, USA, is typically considered safe for solo female travelers. Known for its historic downtown area and scenic riverfront, it tends to be quite tourist-friendly. While crime rates are slightly higher than the national average, they are mostly related to property crimes rather than violent crimes. Nonetheless, like everywhere, it's important to always be aware of your surroundings. Overall, Hannibal is no less safe than any other small to mid-size city in the United States.