Guymon, located in Oklahoma, is a quiet and friendly town that is generally safe for solo female travelers. The crime rate is relatively low and locals are typically hospitable. However, as with any location, it's important to be cautious, particularly at night and in less crowded places. It's advisable to stay in well-populated areas, keep loved ones informed of your whereabouts, and maintain basic safety measures, such as not accepting rides from strangers.