Cape Girardeau, located in Missouri, United States, generally enjoys a good level of safety, especially in the day. As a solo female traveler, you should expect to feel comfortable exploring the city's historical landmarks, riverfront, and cultural centers. However, like in any other location, it's advisable to stay cautious, especially during late hours, and avoid less populated areas or poorly lit streets. It's always recommended to follow the general safety guidelines such as not displaying expensive belongings and maintaining awareness of your surroundings.