Uyo generally holds a level of safety for solo female travelers, however, it's advisable to always be cautious. While the locals are often friendly and helpful, there can be occasional instances of petty crime and trickery. Public transportation isn't always reliable and it's safer to travel during the day. Additionally, ensure to dress modestly as this respects local culture and prevents unwanted attention. Always ensure someone knows your plans for the day and stay in your comfort zone while exploring.