Mellieha is generally a safe area, even at night, as Malta is considered one of the safest countries in Europe. However, keep in mind that no location is perfectly safe, so always use common sense and situational awareness. Typically, the streets remain quite active until midnight, especially in the tourist season, and are well-lit. There is also a consistent police presence which helps in maintaining safety. Always stick to populated areas whenever possible and avoid dark and deserted areas at night.