San Giovanni Rotondo, is generally a safe place for solo female travelers. The locals are friendly and hospitable, and crime rates are low. However, as with any location, a few safety precautions are appropriate. Always be aware of your surroundings, especially at night or in less crowded areas. Furthermore, learn a few essential phrases in Italian just to navigate through the day more effectively, as not everyone will speak English. But rest assured, this is a welcoming and peaceful destination full of rich history and culture.