Vrindavan is reasonably safe for solo female travelers. The locals are generally friendly and respectful, however, they are not as accustomed to female travelers, especially those from foreign countries. As it's a religious town, it is advisable to dress modestly, avoiding revealing attire. Like any travel destination, it is recommended to be cautious of your surroundings, especially during the evenings and in crowded places. Moreover, avoid isolated areas and always opt for accommodations in well-traveled parts of the city.