Mathura, known as the birthplace of Lord Krishna, is relatively safe for solo female travelers. However, appropriate caution should be taken especially during the crowded festival season. As with any travel destination, it's important to stay vigilant about personal belongings and try not to venture out alone late at night in less crowded areas. Always adhere to local customs and dress modestly to respect the local tradition and culture. Predominantly, people are friendly and helpful, but avoid accepting food or drink from strangers as a basic safety measure.