Mangalore is generally considered safe for solo female travelers. The crime rate is relatively low and police are responsive. Local people are often very friendly and willing to help travelers. However, like any other place, it is advised to maintain your vigilance, avoid isolated areas especially after dark, and be respectful of cultural norms and dressing etiquette. Public transport can get crowded, and it's preferable to take prepaid taxis if you need to travel at night.