Puerto Lopez is generally a safe destination for solo female travelers. Like most tourist destinations, occasional petty theft can occur, so it's important to stay vigilant, especially at night. The locals are friendly, the police are usually visible, and the city is making a lot of efforts to improve tourist security. It's recommended to use reputed tour operators for any excursions, keep your belongings secure, and avoid deserted areas during late hours. The majority of travelers have a hassle-free experience.