Misahualli is generally considered a secure destination for solo female travelers. The local community is friendly and welcoming, however, like in any location, it's wise to practice common safety precautions. Always keep your belongings close to you, avoid venturing out alone at night, and stay in well-populated areas. There isn't a prominent crime rate that specifically targets tourists but problems may rise from opportunistic thieves. Overall, the risk is minimal as most visits are trouble-free.