Quepos is generally safe for solo female travelers. The town is friendly, relatively small and full of tourists. Many locals know English which makes communication easier. Overall, people are welcoming and respectful. However, like any place around the world, it's always a good idea to stay cautious, especially at night, and avoid walking alone in isolated areas. Street crime such as petty theft does occur, and it's advisable to keep valuables secured. It's also recommended to use reliable transportation. Even though it's not common, incidents tend to happen so you should always stay alert.