Southern Thailand and the Andaman Coast are generally safe for solo female travelers. The locals are welcoming and friendly, plus the tourist infrastructure is developed enough to provide a sense of security. However, as with any travel, it's important to stay alert, especially at night, and to avoid isolated areas. It's also advisable to respect local traditions and norms to ensure a smooth trip. Always keeping your belongings secure and using registered, reputable transportation options can add to your overall safety.