Pisco is a fairly safe city when practicing typical travel cautions. It is generally safe to walk around during the day, but nighttime is best to avoid unless you are in a group. Be aware of your surroundings at all times and avoid displaying expensive items. Understanding some basic Spanish would be useful for communication. The city's crime rate is not particularly high compared to other cities of Peru, but the occasional pickpocketing or bag snatching incidents have been reported. Notably, Pisco is relatively safe from severe weather conditions or dangerous wildlife. Overall, it's advisable for solo female travelers to stay vigilant and follow safety precautions when exploring Pisco.