Gauteng can be quite challenging for solo female travelers in terms of safety. The region has high crime rates, from pickpocketing and muggings to carjackings, particularly in Johannesburg. It is essential to remain vigilant at all times, avoid unnecessary travel at night, and stay in reputable accommodations. Public transport can be unpredictable, and it's advisable to use known and trusted taxi services. Always follow the advice of locals regarding what neighborhoods are safe to visit. With the right precautions, however, you can have an enjoyable journey.