Vila Real de Santo Antonio is generally a safe place for solo female travelers. It is a peaceful town known for its hospitality and friendly locals. Like most places, it's always essential to maintain awareness of your surroundings and keep your valuables safe, especially while at the beach or crowded places. The town is well-lit and people tend to be helpful, contributing to a sense of security. However, it's always recommended to stay alert and abide by standard safety precautions to avoid potential risks.