Pisac is generally a safe destination for solo female travelers. The locals are friendly towards tourists and often willing to help. However, like in any other location, it's essential to stay alert and cautious. Avoid wandering alone at night and keep your belongings secure at all times to avoid petty theft. Always respect local customs and traditions for a peaceful travel experience. There may be occasional reports of pickpocketing in crowded areas, but incidences of serious crimes are quite rare. Learn a bit of Spanish to help communicate with locals as very few of them speak English.