Tequisquiapan is generally a safe destination for solo female travelers. The city is small, picturesque and its crime rates are low compared to larger Mexican cities. Nevertheless, like in any other place, it's important to remain vigilant, as petty crime can occur. The locals are typically welcoming and helpful, enhancing the sense of safety. However, always remember to adhere to standard safety practices such as avoiding deserted areas at night, not showing off valuables, and keeping an eye on your drink in social settings.