Tepoztlan is generally considered a safe destination for solo female travelers. The locals are friendly, and the town has a slow, laid-back atmosphere that can make visitors feel at ease. It's a popular destination for spiritual and wellness retreats, which adds to its overall peaceful environment. However, like any city around the world, it's always important to stay aware of your surroundings, and avoid risky areas, especially at night. Use common sense, and always take local advice on safety precautions.