Patzcuaro is generally considered a safe destination even for solo female travelers. There is low violent crime and locals are warm, hospitable, and willing to help. However, like in any destination, you should always be cautious and aware of your surroundings. It's important to avoid isolated areas or streets late at night, keep your belongings secure, and use licensed taxis or trusted ride services whenever possible. As a precaution, always inform someone about your whereabouts and keep emergency numbers handy.