Samos is generally quite safe for solo female travelers. Like most destinations, it does require common sense and awareness of one's surroundings, especially during the night. The Greeks are friendly and welcoming, but as in any situation, it's important to stay vigilant. Stay in populated areas, avoid secluded places after dark, and remain alert at all times. It's not uncommon for locals and other tourists to go out of their way to assist solo travelers. Make sure to know some basic Greek phrases and have your accommodation details in case you need help.