Rio Branco is a moderately safe city. As with many other destinations in Brazil, you need to exercise caution. Street crimes such as pickpocketing, bag snatching, and scams are common, so it's important to take basic precautions. Avoid flaunting valuables publicly, stay alert of your surroundings, and avoid wandering alone at night, especially in poorly lit or less crowded areas. Always opt for secure transportation and stay in accommodations with good reviews regarding safety. Public protests may also happen, so steer clear of such incidents to avoid potential violence or unrest. While people are generally sociable, knowing some basic Portuguese can help deal with local residents efficiently. In summary, your safety largely depends on how cautious and alert you are.