Presidente Prudente, located in Sao Paulo's state of Brazil, is generally safe for solo female travelers as long as precautions are taken. Some parts of the city are safer than others so it is recommended to do your research before heading out, especially at night. As with any destination, always be aware of your surroundings, avoid isolated areas, be mindful of your belongings and avoid attracting unwanted attention by dressing modestly. It's also wise to learn a few basic phrases in Portuguese for emergencies.