Hoedspruit is moderately safe for solo female travelers. As in any travel destination, you should maintain a high level of vigilance. While the crime rate is relatively low compared to major cities in South Africa, minor crimes like bag-snatching and pick-pocketing can happen. Always keep an eye on your belongings and avoid isolated areas at night. Wildlife reserves are generally safe, but ensure that you are with a reputable guide or group. Locals are friendly and helpful to foreigners.