Cruz Bay, US Virgin Islands is generally safe for solo female travelers. Like any destination, it's always important to stay vigilant, especially at night, but locals are typically friendly and willing to help. Crime is low but not unheard of, mainly non-violent property crimes like petty theft. It's always sensible to avoid deserted and poorly lit areas at night and always lock your accommodations when you leave. Tourism is a major source of income for the locals, who are often protective of their visitors.