El Puerto de Santa Maria in Spain is generally a safe place for solo female travelers. It's an easy going and friendly city where tourists are welcome. The crime rate is low, and people often go about their daily lives without experiencing any significant issues. However, like any city, it's important to stay vigilant, especially during the night or when visiting secluded areas. It's also beneficial to learn a few words in Spanish as not everyone speaks English. With common-sense precautions, you should have a safe and enjoyable stay.