Gisenyi is generally safe for solo female travelers. However, like anywhere, it's important to take precautions. Rwanda is one of the safest countries in Africa, with low rates of crime. The locals are friendly and willing to help should you need direction or assistance. In Gisenyi, tourism is quite common, which further aids in safety as the locals are accustomed to foreigners. Nevertheless, ensure you avoid walking alone at night, be cautious of your belongings at all times, and use registered taxis for late-night travel.