Nosy Be can be considered moderately safe for solo female travelers. The local people are generally friendly and helpful. However, it's always advised to take common safety precautions, especially during the night. Also, it's important to be cautious while dealing with local transportation and avoid remote areas, especially after dark. Stick to tourist areas wherever possible. It's beneficial to learn a few words of the local language, Malagasy, to help navigate and communicate your needs better.