Chiquimula, like many places in Guatemala, offers a vibrant cultural experience. However, it also has its safety concerns. While violent crime against tourists is not overly common, petty theft and pickpocketing can happen, particularly in crowded places. Female travelers are generally safe, but it's recommended to avoid traveling alone at night. Always stay aware of your surroundings, especially in isolated areas. Use reputable transportation services and keep your valuables out of sight. While people are generally friendly, the level of spoken English may be low outside tourist areas, so having some Spanish phrases can be beneficial.