Calama is generally a safe city for solo female travelers due to its low crime rates. However, like any other destination, it's always important to maintain alert and aware of your surroundings, especially while traveling alone. It's recommended to stick to populated areas and avoid venturing out late at night. While the locals are usually friendly and helpful, minimal knowledge of Spanish could be beneficial. Precautions should be taken by not flaunting valuable items or large amounts of cash in public.