Iquique is generally considered safe for solo female travelers. There is a strong police presence throughout the city, and locals are friendly and helpful. Most of the city areas are well lit at night and buses and taxis are reliable and safe. However, just like any other place in the world, it's important to exercise caution and be aware of your surroundings, particularly in less crowded areas at night. Always keep your belongings close, and stay in well-populated areas, especially after dark.