Kampong Cham is a fairly safe destination for solo female travelers. The local people are generally friendly and helpful, and serious crime is relatively low. However, it is advisable to remain cautious at all times, especially at night or in less populated areas. Like in any other destination, it is important to respect local customs and cultures, and ensure your belongings are secured. It is also advised to book accommodation in advance, stick to populated areas especially during the night and use reputable transportation.