The Central Kalahari Game Reserve in Botswana is generally deemed as safe for solo female travelers. Opting to go with a reputable tour operator can further ensure your safety. The locals are friendly and crime rate in Botswana is relatively low. However, as a remote area, ensuring that you have a method of communication in emergencies is crucial. As with any travel experience, it pays to be cautious and aware of your environment. Always respect local customs, rules, and regulations.