De Panne is considered a rather safe location for solo female travelers. The crime rate in the city is generally low and the locals are known for being helpful and courteous. Public transportation is reliable, and it is easy to get around by foot or by bike as the city is well-lit and maintained. Still, as with any location, it's always a good practice to maintain general precautions such as not walking alone late at night and keeping your belongings secure at all times.