San Martin de los Andes in Argentina is generally safe for solo female travelers. The town is known for its friendly locals and peaceful atmosphere. As with any destination, it is always recommended to maintain typical travelling precautions such as avoiding isolated areas at night and being aware of one's surroundings. It's also a good idea to keep your personal belongings secure at all times to avoid pickpocketing. While crime rates are relatively low, it’s always better to be safe and vigilant at all times.