Puerto Madryn is relatively safe, although like any place, it comes with its share of risks. Generally, the city has low crime rates and locals tend to be friendly and helpful. However, it may not be advisable to walk alone at night, especially in deserted or poorly lit areas. If you have to move around at night, consider using trusted transport options, like taxis or Uber. Always stay alert, avoid showing obvious signs of wealth and don't carry large amounts of money or valuables. Remember that your safety largely depends on your own precautions and attention to your surroundings.