Puerto Madryn is generally a safe city for solo female travelers. Like in many cities, it's always important to be aware of your surroundings, especially after dark. Non-violent petty crime such as pickpocketing can occur, particularly in crowded places or tourist areas, so keeping your belongings secured and being mindful of your surroundings can help avoid such instances. If you use common sense and follow standard safety precautions, your trip should be enjoyable and safe.