Izamal is generally safe for solo female travelers. Locals are friendly and willing to help, making it a comfortable place to explore. However, like any other place, be attentive to your surroundings, avoid venturing into isolated areas late at night, and always keep your personal belongings close to prevent theft. Brief interactions with street vendors can be expected but they are typically non-threatening. Local law enforcement is also seen visibly around the city, providing an extra layer of security.