Itanhaém is generally considered a moderate safety destination for solo female travelers. The city is mostly safe during daylight hours if you stay on main roads and busy areas, but it's important to always be aware of your surroundings. Very careful at night, avoid poorly illuminated areas and try to stay in populated areas. Always keep your belongings secure and avoid flashing expensive items to deter pickpockets. As always, it's recommended to learn some key phrases in Portuguese to help in navigating situations. It's advisable to check latest travel advisories before planning travel.