Mandalay, as a travel destination, offers great cultural experiences but it's not without challenges. While crimes targeting tourists are not common, there could be issues related to general safety such as road accidents due to poor driving habits of locals. It is always wise to stay cautious, avoid isolated or poorly lit areas late at night, and keep your belongings secure. Solo female travelers should be extra cautious at night. As with travel anywhere, it is important to respect local customs and dress appropriately.